Genetic associations in beta‐lactam allergy
نویسندگان
چکیده
منابع مشابه
Genetic associations in beta-lactam allergy
Immediate reactions to beta-lactams (BLs) are the most common allergic reactions against drugs and can be lifethreatening. The genetic risk factors influencing these reactions are poorly known, except those which were previously identified as predictors of atopy and inflammation. Two polymorphisms of nucleotide-binding oligomerization domain 2 (NOD2), a gene associated with chronic inflammatory...
متن کاملPlacebo controlled drug provocation testing (PCDPT) to betalactam and non-betalactam antibiotics and its diagnostic value in drug allergy diagnostics
Method All the patients underwent PCDPTs to betalactam and non-betalactam antibiotics from the 1st of October 2008 to the 1st of October 2013 in our department reported about one or more adverse side reactions to antibiotic in the background and underwent standard diagnostic procedures prior PCDPT. We compared the results of diagnostic procedures such as in vivo skin testing and in vitro labora...
متن کاملContinued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams.
Immediate allergic reactions to betalactams (BLs) are due to IgE antibodies that recognize the ring-derived penicilloyl determinant or side-chain structures of common BLs. The presence of specific IgE antibodies can be demonstrated by skin testing, the determination of specific IgE antibodies in sera or their binding to basophils with subsequent activation upon contact with penicillins in vitro...
متن کاملDrug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value.
BACKGROUND There are no studies on cross-reactivity of betalactams among patients allergic to penicillin, or on the negative predictive value (NPV) of penicillin allergy evaluation from Arabian Gulf countries. OBJECTIVE We aimed to assess the role and NPV of drug provocation test (DPT) for betalactam hypersensitivity reactions in patients referred for allergy evaluation in Kuwait. METHODS S...
متن کاملBasophil activation and sulfidoleukotriene production in patients with immediate allergy to betalactam antibiotics and negative skin tests.
BACKGROUND New in vitro diagnostic methods for IgE-mediated drug allergic reactions, such as basophil activation test and antigen specific sulfidoleukotriene test, have proven their usefulness in patients with positive skin tests. OBJECTIVE To assess the usefulness of basophil activation test and antigen specific sulfidoleukotriene test in the diagnosis of patients with IgE-mediated allergy t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2014
ISSN: 2045-7022,2045-7022
DOI: 10.1186/2045-7022-4-s3-p68